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July 1972

Tissue Culture of Kaposi's Sarcoma

Author Affiliations

Los Angeles

From the University of Southern California School of Medicine, Section of Dermatology, Los Angeles (Drs. Levan, Korn, and Rounds); and the Pasadena (Calif) Foundation for Medical Research (Mr. Booher and Dr. Rounds).

Arch Dermatol. 1972;106(1):37-40. doi:10.1001/archderm.1972.01620100025006

The concomitant application of tissue culture, phase contrast microscopy, and time-lapse cinematography offers enhanced opportunities for the study and possible identification of living cells. This union of techniques was applied to Kaposi's sarcoma, whose histogenesis remains uncertain a century after its first description. Explants were prepared from biopsy specimens of cutaneous lesions of Kaposi's sarcoma. Tissue cultures in Rose chambers were observed for two to six weeks. Four morphologically distinct cell types were characterized in these cultures, of which the most significant is the spindle-shaped cell. This cell exhibited aspects of the Schwann cell in culture.