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July 1972

Chronic Granulomatous Disease of ChildhoodSuperficial Pyoderma as a Major Dermatologic Manifestation

Author Affiliations

Ann Arbor, Mich

From the Department of Dermatology (Drs. Bass, Voorhees, and Dubin), and the Infectious Disease Section, Department of Internal Medicine (Dr. Tanner), University of Michigan Medical School, Ann Arbor.

Arch Dermatol. 1972;106(1):68-71. doi:10.1001/archderm.1972.01620100054012

A patient had chronic granulomatous disease of childhood (CGD) with an indolent superficial pyoderma. Sixty-three of 92 cases (68%) of CGD in the world literature were associated with some form of superficial pustular dermatosis including impetigo, infected seborrheic dermatitis, and infectious eczematoid dermatitis. Thirty-three (35%) of these cases exhibited pyoderma as the sole initial manifestation of the disease. The importance of chronic, indolent, superficial pyoderma as an early manifestation of CGD is discussed in relation to therapy, follow-up, and genetic counseling.