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To the Editor.—
This letter is in reference to an article by Fisher et al which appeared in the September issue of the Archives (104:286, 1971).Following Dr. Fisher's recommendation for a vehicle tray, we have begun using such a tray in the Dermatology Clinic at Letterman General Hospital. In the first three patients tested, the only positive reactions have been 4+ vesicular eruptions at the site of application of phenylmercuric acetate 0.1% in petrolatum.This, of course, suggested that the reaction was an irritant rather than contact dermatitis. I therefore treated myself with the same substance and found I was unable to tolerate the patch longer than 24 hours. Upon removing it, I found again, as in three out of three previous patients, a 4+ vesicular patch test reaction.I would like, therefore, to respectfully suggest that phenylmercuric acetate is capable of eliciting an intense primary irritant reaction and
Koby GA. Phenylmercuric Acetate as Primary Irritant. Arch Dermatol. 1972;106(1):129. doi:10.1001/archderm.1972.01620100103030