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August 1972

Cicatricial PemphigoidImmunofluorescent Studies

Author Affiliations

Houston; Cleveland; Houston; Cleveland

From the Department of Dermatology, Baylor College of Medicine, Houston (Drs. Bean and Knox), and the Division of Dermatology (Drs. Waisman and Michel) and the Department of; Ophthalmology (Drs. Thomas and Levine), Case Western Reserve University School of Medicine, Cleveland.

Arch Dermatol. 1972;106(2):195-199. doi:10.1001/archderm.1972.01620110031007

Direct immunofluorescent staining of specimens from the conjunctiva, buccal mucosa, and skin of four patients with cicatricial pemphigoid revealed the presence of tissue-fixed, basement membrane zone antibodies similar to the basement membrane zone fluorescent staining characteristic of bullous pemphigoid. No circulating basement membrane zone antibodies could be detected in the sera of these patients. These findings suggest a relationship between cicatricial pemphigoid and bullous pemphigoid and that cicatricial pemphigoid may represent a forme fruste of bullous pemphigoid with predilection for mucous membrane and a tendency to scarring.