Direct immunofluorescent staining of specimens from the conjunctiva, buccal mucosa, and skin of four patients with cicatricial pemphigoid revealed the presence of tissue-fixed, basement membrane zone antibodies similar to the basement membrane zone fluorescent staining characteristic of bullous pemphigoid. No circulating basement membrane zone antibodies could be detected in the sera of these patients. These findings suggest a relationship between cicatricial pemphigoid and bullous pemphigoid and that cicatricial pemphigoid may represent a forme fruste of bullous pemphigoid with predilection for mucous membrane and a tendency to scarring.
Bean SF, Waisman M, Michel B, Thomas CI, Knox JM, Levine M. Cicatricial PemphigoidImmunofluorescent Studies. Arch Dermatol. 1972;106(2):195-199. doi:10.1001/archderm.1972.01620110031007