[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.129.96. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
August 1972

Acne VulgarisOral Therapy With Tetracycline and Topical Therapy With Vitamin A

Author Affiliations

Philadelphia

From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia.

Arch Dermatol. 1972;106(2):200-203. doi:10.1001/archderm.1972.01620110036009
Abstract

Over an eight-week period, three treatments for moderately severe acne were compared in groups of adolescents: (1) 0.05% daily vitamin A acid (retinoic acid) alone; (2) demeclocycline hydrochloride alone, 600 mg a day for the first three weeks, 300 mg thereafter; (3) a combination of the two. In addition to clinical assessment, subjects in each group were studied with regard to the relationship of free fatty acids (FFA) to the density of Corynebacterium acnes.

The combination therapy produced the swiftest and greatest effect on all three factors: therapeutic benefit, decreased FFA, and reduction in the anaerobic microflora.

It was postulated that vitamin A potentiated the effect of demeclocycline by bringing about an increased tissue concentration of the antibiotic.

×