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September 1972

Histiocytic Medullary Reticulosis With Cutaneous Lesions

Author Affiliations

USA; USA; USA, Honolulu

From the Department of Medicine, sections of dermatology (Drs. Aeling and Suringa) and hematology (Dr. Engstrom), USA Tripler General Hospital, Honolulu. Dr. Engstrom is now with the American Oncologic Hospital, Philadelphia; Dr. Aeling is now with USA Fitzsimmons General Hospital, Denver.

Arch Dermatol. 1972;106(3):369-371. doi:10.1001/archderm.1972.01620120053011

Histiocytic medullary reticulosis (HMR) is a rare, uniformly fatal, acute disease of the reticuloendothelial system. The disease is associated with fever, purpura, jaundice, hepatosplenomegaly, lymphadenopathy, and pancytopenia. A patient with HMR is described who had multiple, brown-to-violaceous tumors and plaques in the skin. A biopsy taken from a skin lesion showed the unique histologic finding of HMR, ie, phagocytosis of erythrocytes, platelets, and nuclear debris, by large, atypical histiocytes.