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September 1972

Electron Microscopy in the Diagnosis of Amyloidosis

Author Affiliations

Augusta, Ga

From the Department of Dermatology, Medical College of Georgia, and the Veterans Administration Hospital (Dr. Goodman), Augusta, Ga.

Arch Dermatol. 1972;106(3):393-397. doi:10.1001/archderm.1972.01620120077024

A patient had primary amyloidosis which showed typical cutaneous manifestations. Histochemical stains normally used in the diagnosis of amyloidosis were inconclusive. Therefore, diagnostic electron microscopic studies were carried out to assist in definitive diagnosis. The electron microscopic findings showed characteristic amyloid fibrils deposited free in the dermis, associated with collagen bundles, and around small blood vessels.