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October 1972

Ultraviolet Radiation and Psoriasis

Author Affiliations

Birmingham, England

From the Skin Hospital and Medical Research Council Unit on the Experimental Pathology of the Skin, the University of Birmingham, Birmingham, England.

Arch Dermatol. 1972;106(4):498-502. doi:10.1001/archderm.1972.01620130030007

The macroscopic and microscopic reactions of nonpsoriatic and clinically uninvolved psoriatic skin to ultraviolet radiation (UVR) showed no gross differences. The erythema threshold was decreased in subjects whose psoriasis was in an acute, eruptive stage. On the basis of studies of epidermal DNA synthesis, ultraviolet radiation resulted in an injury response at 48 hours in normal subjects and in psoriatic patients in whom the disease was in an acute, eruptive stage. The injury response to UVR was significantly decreased in those subjects with chronic, nonerutive psoriasis and the reason for this is unexplained.