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November 1972

Fixed Drug Eruption (Phenolphthalein)Evidence for a Blood-Borne Mediator

Author Affiliations

Newcastle Upon Tyne, England

From the University Department of Dermatology and Wellcome Research Laboratories, Royal Victoria Infirmary, Newcastle Upon Tyne, England. Dr. Søndergaard is presently at the University Department of Dermatology, Rigshospital, Copenhagen, and Dr. Wyatt is presently with the Department of Dermatology, Hull Royal Infirmary, Hull, England.

Arch Dermatol. 1972;106(5):671-673. doi:10.1001/archderm.1972.01620140019006

Experiments were carried out in an elderly lady with fixed drug eruption (phenolphthalein). Negative results were obtained to patch and intradermal testing, skin perfusion techniques, and an in vitro challenge system. For the first time in the literature, we were able to show that cooled stored serum taken from the height of an attack and injected intradermally will produce a local inflammatory response. The serum factor responsible is a thermolabile substance.