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Article
November 1972

Histologie Artifacts of Benign Pigmented Nevi

Author Affiliations

San Francisco

From the Department of Pathology, Children's Hospital of San Francisco, 3700 Calif St, San Francisco.

Arch Dermatol. 1972;106(5):691-693. doi:10.1001/archderm.1972.01620140039011
Abstract

Artifacts of benign pigmented nevi presumed to be shrinkage during tissue-processing are described. These produce separation into clefts or nests leaving spaces that simulate lymphatic or vascular spaces. The artifact was found in 10% of 350 otherwise unremarkable benign pigmented nevi. Actual lymphatic invasion probably also occurs in benign nevi but was observed in only one instance. A second artifact results in nevus cells separating into parallel rows. The latter artifact was reproduced in ten experimental subjects by intralesional injections of local anesthetic, and involved from 10% to 90% of the cross-sectional area of the nevus. Knowledge of these artifacts can prevent misdiagnosis or subclassification of these histologie artifacts.

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