Penile Granuloma. Presented by Wilfred Minkin, MD, Samuel B. Frank, MD, and Harvey J. Cohen, MD.
The patient, a 54-year-old black man, has had a gradually enlarging penile ulcer (Fig 1) for the past five months.On two occasions, biopsy specimens were described by Dr. Lewis Shapiro as showing a granulomatous process with foci of necrosis. There was no evidence of carcinoma. The results of the following diagnostic tests were negative: stains for acid-fast bacilli, culture for acid-fast bacilli, Giemsa-stained smears and tissue sections for Donovan bodies, urine culture for acid-fast bacilli, culture for fungi, skin tests for fungi and autoinoculation for Hemophilus ducreyi.A serologic test for syphilis (VDRL) was weakly reactive, and the fluorescent treponemal antibody test was positive. Skin test with intermediate PPD resulted in an indurated area 1 cm in diameter.The process has been treated in the following ways: (1) tetracycline, 2 gm daily for
Cohen HJ. THE DERMATOLOGIC SOCIETY OF GREATER NEW YORK. Arch Dermatol. 1972;106(5):756-759. doi:10.1001/archderm.1972.01620140094027