One percent haloprogin cream, a topical agent for the treatment of dermatophytoses, has proved efficacious in experimentally induced and naturally occurring human infections. These studies indicate haloprogin cream to be significantly (P<.05) more effective than placebo treatment. Efficacy was confirmed by a high percentage of clinical improvement, KOH reversals, and negative cultures. Simultaneously, by double-blind paired comparison and parallel studies, as well as open studies, 12 of these same investigators showed significantly (P<.05) greater efficacy of 1% haloprogin solution over placebo. Both haloprogin formulations were comparable to tolnaftate in the therapy of dermatophytoses.
Hermann HW. Clinical Efficacy Studies of Haloprogin, a New Topical Antimicrobial Agent. Arch Dermatol. 1972;106(6):839-842. doi:10.1001/archderm.1972.01620150025009