A young man with a severe eruption of keratosis follicularis (Darier's disease) of long duration had failed to respond to continuous administration of vitamin A in large doses over a five year period. Seven months after adding vitamin E in a dose of 1,200 international units (IU) daily and continuing vitamin A, the eruption had improved approximately 75%.
It is speculated that the striking improvement in this recalcitrant case was due to a synergistic action of vitamin E with vitamin A, previously demonstrated experimentally. If these results can be duplicated, it would suggest the advisability of the combined administration of these vitamins in those conditions where vitamin A is indicated, thus facilitating its utilization and lessening the danger of hypervitaminosis A by reducing the amounts required for a therapeutic effect.
Ayres S, Mihan R. Keratosis Follicularis (Darier's Disease)Response to Simultaneous Administration of Vitamins A and E. Arch Dermatol. 1972;106(6):909-910. doi:10.1001/archderm.1972.01620150091028