Most of 251 patients with atopic dermatitis had itchy follicular papules, mainly on the lateral parts of the trunk rather than on the extensor surfaces of the extremities. Biopsy specimens of the papules showed spongiosis and vesicle formation at the upper portion of the follicles which were surrounded and penetrated by mononuclear cells. Such an inflammatory change was absent in the surface epidermis adjacent to the follicles. It is suggested that the follicular papule is an essential lesion, probably a first visible eruption of atopic dermatitis.
Ofuji S, Uehara M. Follicular Eruptions of Atopic Dermatitis. Arch Dermatol. 1973;107(1):54-55. doi:10.1001/archderm.1973.01620160026005