Thirteen patients had a distinctive annular, nonscarring granuloma affecting the forehead and face. The lesions appear predominantly in women in early middle life and are not frequently associated with clinical diabetes mellitus.
Histopathologic changes reveal a granulomatous pattern with marked tendency toward multinucleated giant cell reaction and with no necrobiosis.
The term ``Miescher's granuloma of the face" is proposed for the condition. We feel that Miescher's granuloma of the face is a clinically and histologically distinct entity within the spectrum of diseases that include necrobiosis lipoidica and granuloma annulare.
Mehregan AH, Altman J. Miescher's Granuloma of the FaceA Variant of the Necrobiosis Lipoidica-Granuloma Annulare Spectrum. Arch Dermatol. 1973;107(1):62-64. doi:10.1001/archderm.1973.01620160034009