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January 1973

Familial Cold Urticaria

Author Affiliations

Groningen, The Netherlands

Arch Dermatol. 1973;107(1):136-137. doi:10.1001/archderm.1973.01620160096035

To the Editor.—  Familial cold urticaria (FCU), in contrast to acquired cold urticaria, is a rare disease. Symptoms in FCU are caused by exposure to cold air rather than cold water; a skin test with ice cubes is negative; it has a latency period of up to several hours; and the skin lesions are erythematous more often than urticarial. Skin symptoms in FCU may be accompanied by fever, chills, and painful edematous swelling of the extremities together with leukocytosis. Passive transfer tests with serum are always negative, whereas they are frequently positive in acquired cold urticaria.So far, six pedigree charts have been reported,1-6 to which we would like to add a seventh (Figure). This excludes the type of family described by Shepard,7 which suffered from cold urticaria and amyloidosis.The trait is transmitted as an autosomal dominant one; more than half of the family members have symptoms

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