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Article
February 1973

Ecologic Principles and Antibiotic Therapy in Chronic Dermatoses

Author Affiliations

Philadelphia

From the Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia.

Arch Dermatol. 1973;107(2):208-211. doi:10.1001/archderm.1973.01620170020006
Abstract

Long-term antibiotic usage can induce ecologic shifts in the cutaneous microflorawhich are of therapeutic importance. Suppression of a portion of the microflora is followed by the void being filled with new organisms, some of which may be pathogens. Clinical exacerbations, after initial improvement, should alert the physician to the possibility of such ecologic successions. Examples of this principle are documented in five chronic dermatoses in which antibiotics are frequently used.

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