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Morphea and Fixed Drug Eruption. Presented by Anthony N. Domonkos, MD.
Within the past three years, a 53-year-old housewife developed two symmetrical plaques over the anterior iliac crests, yellowish ivory, hard, dry, and smooth. In addition, symmetic hyperpigmented patches have developed on the abdomen. Over the lower mid-back and right forearm are similar brownish-black patches which are nonscaling and appear in normal skin.The patient was able to provide a list of about 30 drugs now being taken, or taken during the development of the lesions which included: vitamin A (50,000 units daily), Saraka, Librium, Benadryl, Sinutabs, Sinubids, Colace, Naqua, Teldrin, Valium, Percodan, vitamin B, Lotusate, Bonase, Synthroid, Cytomel, Premarin, Nalderon, Brom-Quinine, Donnatol, Stelazine, Bufferin, Excedrin, Cascara, and Caroid and Bile Salt Tablets.A biopsy specimen taken from the hip area showed sclerotic connective tissue compatible with scleroderma. The hyperpigmented area showed only minimal changes, with "overactivity" of the epidermal
Atkinson S. THE NEW YORK DERMATOLOGICAL SOCIETY. Arch Dermatol. 1973;107(2):289-291. doi:10.1001/archderm.1973.01620170093028