A prospective study of ten patients with early pemphigus, who were treated with azathioprine, is described. The dosage of azathioprine was 50 to 250 mg/day. Nine of the ten patients had good to excellent results. Seven of the ten patients were either never given corticosteroids or had the corticosteroids completely withdrawn. There was good clinical and immunologic correlation in eight of the ten patients. There were no significant side-effects and no wound-healing problems. High-dose corticosteroid therapy is still the treatment of choice for severe, generalized, toxic pemphigus, but in early pemphigus azathioprine alone may control the disease.
Roenigk HH, Deodhar S. Pemphigus Treatment with AzathioprineClinical and Immunologic Correlation. Arch Dermatol. 1973;107(3):353-357. doi:10.1001/archderm.1973.01620180007002