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March 1973

Resistant PsoriasisCombined Methoxsalen-Anthralin Therapy

Author Affiliations

USA; USA, San Francisco

From the Dermatology Research Division, Letterman Army Institute of Research, Presidio of San Francisco. Dr. Willis is now with the Sub-Department of Dermatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore. MAJ Harris is with the Department of Dermatology, Veterans Administration Hospital, Palo Alto, Calif.

Arch Dermatol. 1973;107(3):358-362. doi:10.1001/archderm.1973.01620180012003

Topically applied methoxsalen solution photoactivated by blacklight was combined with a low-strength anthralin paste regimen for the treatment of resistant psoriasis. Initial trials resulted in complete clearing at test sites within one to three weeks, while recalcitrant lesions at control sites remained relatively unaffected. The authors suggest a type of synergism is produced analogous to modern cancer treatment where chemotherapy and selective irradiation are combined to effect control.