A combination of methotrexate and hydroxyurea therapy was administered to 14 patients with severe psoriasis. With administration of approximately half the dose of methotrexate and half the dose of hydroxyurea (Hydrea) previously used for these patients, the clinical response was adequate in 13 cases and there was no worsening of the laboratory test results in 11 of the patients. It is suggested that further careful studies be done to prove there is an advantage to combination chemotherapeutic therapy for psoriasis.
Sauer GC. Combined Methotrexate and Hydroxyurea Therapy for Psoriasis. Arch Dermatol. 1973;107(3):369-370. doi:10.1001/archderm.1973.01620180023006