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March 1973

Reactive Perforating Collagenosis

Author Affiliations

Bangor, Maine

Arch Dermatol. 1973;107(3):464-465. doi:10.1001/archderm.1973.01620180102037

To the Editor.—  In 1967, Mehregan et al reported the first case in the literature of reactive perforating collagenosis (RPC).1 Later that year, J. Weiner reported two cases diagnosed as Kyrle's disease occurring in a brother and sister,2 which on review by Mehregan were undoubtedly RPC. Including Bovenmyer's case of RPC,3 and interestingly enough, A. L. Weiner's two cases in siblings,4 Mehregan has had brought to his attention a total of ten cases of this disease,5 only six of which have been reported in the literature.The purpose of this letter is to record two more cases of this disease, occurring in brothers aged 1 and 4, and to add a new clinical variant and its treatment.The disease is so distinctive that, once known, its diagnosis is easily and definitively made. Diagnostic features are as follows: (1) Onset is usually during the first year

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