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March 1973

Electron Microscopy in Amyloidosis

Author Affiliations

Staten Island, NY

Arch Dermatol. 1973;107(3):466. doi:10.1001/archderm.1973.01620180104041

To the Editor.—  In a recent article entitled "Electron Microscopy in the Diagnosis of Amyloidosis" (Arch Dermatol 106: 393-397, 1972), Goodman et al stated: "Some skin diseases have been found to be associated with secondary systemic amyloidosis. Included in this list are hidradenitis suppurativa, stasis ulcers, psoriatic arthritis, dystrophic epidermolysis bullosa, and lepromatous leprosy."While this was certainly just an oversight on their part, we would like to point out that lepromatous leprosy is a systemic disease. Although there is a predilection for the skin and peripheral nerves, many organs may be involved with the exception of the central nervous system. A recent study1 has revealed bacteremia without signs or symptoms of septicemia in 25 of 32 patients with leprosy. In the same report acid-fast bacilli were found in 15 of 18 biopsy specimens of the liver and nine of 14 biopsy specimens of the bone marrow.Secondary systemic

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