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April 1973

Treating Friction Blisters With Alkyl-a-Cyanoacrylates

Author Affiliations

USA, San Francisco; USA, Washington, DC; USA, San Francisco

From the Dermatology Research Division, Letterman Army Institute of Research, Presidio of San Francisco (COL Akers and CPT Cortese), and the United States Army Biomechanical Research Laboratory, Washington, DC (Dr. Leonard and CPT Ousterhout). Dr. Ousterhout's present address is Suite 910, 490 Post St, San Francisco 94102. Dr. Cortese is now with Indiana University Medical Center, Indianapolis.

Arch Dermatol. 1973;107(4):544-547. doi:10.1001/archderm.1973.01620190020004

A series of alkyl-α-cyanoacrylates were investigated as dressings for friction blisters. Of the monomers tested, a viscous isoamyl-α-cyanoacrylate and pentyl cyanoacrylate seemed to be the most effective in regard to relieving pain, preventing infection, and permitting the continuation of work. Applying cyanoacrylate was found more satisfactory than using a mixture of polymyxin B sulfate, neomycin sulfate, and gramicidin (Neosporin Cream) and moleskin treatment.