A 0.05% solution of tretinoin was evaluated in eleven early cases of moderately severe pseudofolliculitis of the beard and in 27 cases in older subjects, including some with long-standing cases of extreme severity.
Daily application was uniformly helpful in the early stages, producing good to excellent results within eight weeks. Severe cases responded poorly. Moderate cases of long standing were benefited to the same degree as those in the initial stages.
Topically applied neomycin added nothing to the result.
Kligman AM, Mills OH. Pseudofolliculitis of the Beard and Topically Applied Tretinoin. Arch Dermatol. 1973;107(4):551-552. doi:10.1001/archderm.1973.01620190027006