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Article
April 1973

Fibrinolytic Activity in Lesions of Hereditary Hemorrhagic Telangiectasia

Author Affiliations

Chicago

From the Department of Medicine, Northwestern University Medical School and Veterans Administration Research Hospital, Chicago.

Arch Dermatol. 1973;107(4):571-573. doi:10.1001/archderm.1973.01620190047011
Abstract

Previous studies of the mechanism of bleeding in hereditary hemorrhagic telangiectasia (HHT) suggest the presence of a local hemostatic abnormality. As the fibrinolytic system is an integral part of the local hemostatic function, the plasminogen activator content of the telangiectatic lesion was studied. Skin and nasal mucosal biopsied specimens were examined by a histochemical fibrin slide method for fibrinolytic activity. The dilated telangiectatic small vessel consistently showed an increase in plasminogen activator. Such findings suggest a role of fibrinolysis in the bleeding. The topical application of aminocaproic acid, an inhibitor of fibrinolysis, effectively arrested epistaxis.

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