Serum IgE levels were determined on 147 patients with atopic dermatitis and other skin disorders, and on pooled serum from 20 nonatopic control subjects. Mean IgE levels of patients with atopic dermatitis were compared with the mean level of pooled normal serum plus subjects with nonatopic dermatoses and found to be significantly higher. Severity of the atopic dermatitis was highly correlated to the levels of serum IgE. Other findings suggested the use of serum IgE determinations in the recognition of atopy in some patients with limited cutaneous involvement or with adult onset of a nonspecific eczematous dermatosis.
Gurevitch AW, Heiner DC, Reisner RM. IgE in Atopic Dermatitis and Other Common Dermatoses. Arch Dermatol. 1973;107(5):712-715. doi:10.1001/archderm.1973.01620200030006