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May 1973

Cutaneous Reaction to Drugs With Special Reference to Severe Bullous Mucocutaneous Eruptions and Sulphonamides

Author Affiliations

San Francisco

Arch Dermatol. 1973;107(5):781. doi:10.1001/archderm.1973.01620200083032

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The diagnosis of cutaneous drug reaction is often made but is so rarely proven that a clear presentation of the extent of the problem has been lacking. This petite monograph, representing ten years of path blazing clinical trials, is a momentous accumulation of most significant data and fills a major hiatus in our knowledge. The courageous author and her colleagues have redosed (provocation testing) 314 patients who were thought to have cutaneous drug reactions on clinical grounds. She has not only developed methods of doing this without serious disability to the patients so tested, but has provided crisp data destroying many shibboleths in the area of clinical allergy. This review is brief, and every dermatologist wishing to place his knowledge of drug reaction on a scientific basis must read this refreshing monograph.

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