Desonide cream, 0.05%, is a new nonfluorinated topical steroid cream. A doubleblind clinical evaluation of 133 patients demonstrates it to be as effective as 0.025% fluocinolone acetonide cream in the treatment of steroid responsive dermatoses with no statistically significant preponderance for either steroid.
Gentry WC, Rosenberg EW, Goltz RW. A Clinical Evaluation of 0.05% Desonide CreamA New Nonfluorinated Topical Corticosteroid. Arch Dermatol. 1973;107(6):870-871. doi:10.1001/archderm.1973.01620210038010