The cases of 19 patients whose symptom of "burning mouth" was associated with the clinical findings of gingivitis, glossitis, and angular cheilitis are presented. Histologic alterations included considerable plasma cell infiltration of the gingival tissue. Discontinuation of gum chewing and use of dentifrices resulted in resolution of the problem in 12 patients; reinstitution of either gum chewing or use of dentifrices precipitated the disease once again in 12 patients. Patch tests of gums and ingredients of dentifrices were disappointing. It would seem that some common ingredient in both chewing gum and toothpastes is responsible, at least in some patients, for the development of this syndrome.
Perry HO, Deffner NF, Sheridan PJ. Atypical GingivostomatitisNineteen Cases. Arch Dermatol. 1973;107(6):872-878. doi:10.1001/archderm.1973.01620210040011