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June 1973

Herpes GestationisHistology and Ultrastructure

Author Affiliations


From the departments of dermatology, Tufts University School of Medicine and New England Medical Center, Boston.

Arch Dermatol. 1973;107(6):888-892. doi:10.1001/archderm.1973.01620210052014

On electron microscopic examination, the most prominent change in a case of herpes gestationis consisted of severe necrosis of the basal cells. The basal lamina usually was located at the floor of the blister. A pronounced cellular infiltrate was found in the dermis and epidermis, consisting mainly of eosinophils and macrophages. It was concluded that the blister formed as the result of disintegration of basal cells and an accumulation of fluid between basal cells and basal lamina.