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Original Contribution
July 1973

HL-A Antigens in Pemphigus

Author Affiliations

Washington, DC; Miami, Fla; Bethesda, Md
From the Dermatology Service, Walter Reed General Hospital, Washington, DC (Drs. Katz and Dahl); the Department of Dermatology, University of Miami and Veterans Administration Hospital, Miami, Fla (Dr. Penneys); Microbiological Associates, Inc. (Dr. Trapani) and the Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md (Dr. Rogentine).

Arch Dermatol. 1973;108(1):53-55. doi:10.1001/archderm.1973.01620220025006

We studied the frequency of 20 human leukocyte (HL-A) alloantigens in 18 patients with pemphigus. HL-A13 was significantly increased as compared to a normal racial control group. Five of the 18 patients (28%) had HL-A13, whereas only 10 of 251 controls (4%) had the same antigen. Sera from patients did not react with their own lymphocytes nor did they have any anti-HL-A antibodies in lymphocytotoxicity tests. Anti HL-A sera did not react with the pemphigus interepithelial antigen in an indirect immunofluorescent test.