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Original Contribution
July 1973

Experimental Infection With Candida albicans

Author Affiliations

From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia. Dr. Marples is now at the Central Public Health Laboratory, London.

Arch Dermatol. 1973;108(1):69-73. doi:10.1001/archderm.1973.01620220041010

Candida albicans, applied to human skin under occlusion for 24 hours, induced a pustular dermatitis, the severity of which was proportional to the size of the inoculum. The 105 cells produced infections in 95% of the patients. Blacks were more resistant than whites, though Candida grew well. Mycelial forms were rare and were not a prerequisite for a take. Infections were readily induced on skin that was stripped to the glistening layer, casting doubt on the importance of anti-Candida serum factors. In atopic and psoriatic skin, infections only occurred when the existing microflora was eradicated. Candida albicans is not a secondary invader in dermatitic skin.