Candida albicans, applied to human skin under occlusion for 24 hours, induced a pustular dermatitis, the severity of which was proportional to the size of the inoculum. The 105 cells produced infections in 95% of the patients. Blacks were more resistant than whites, though Candida grew well. Mycelial forms were rare and were not a prerequisite for a take. Infections were readily induced on skin that was stripped to the glistening layer, casting doubt on the importance of anti-Candida serum factors. In atopic and psoriatic skin, infections only occurred when the existing microflora was eradicated. Candida albicans is not a secondary invader in dermatitic skin.
Rebora A, Marples RR, Kligman AM. Experimental Infection With Candida albicans. Arch Dermatol. 1973;108(1):69-73. doi:10.1001/archderm.1973.01620220041010