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Case Reports
July 1973

Mammary Silicone GranulomaMigration of Silicone Fluid to Abdominal Wall and Inguinal Region

Author Affiliations

Washington, DC; Philadelphia; Washington, DC
From the Registry of Tissue Reactions to Drugs (Dr. Delage) and the Histochemistry Branch (Dr. Johnson), Armed Forces Institute of Pathology, Washington, DC, and the Clinical Laboratory, St. Agnes Hospital, Philadelphia (Dr. Shane). Dr. Delage is now at L'Hôtel-Dieu de Québec, Québec.

Arch Dermatol. 1973;108(1):104-107. doi:10.1001/archderm.1973.01620220066018

Two and one-half years after having had silicone fluid injected into her breasts, a 22-year-old woman noticed two painful masses in the subcutaneous tissue of her abdominal wall. Similar lesions appeared four months later in both breasts and in the inguinal region. Gross and microscopic aspects of these masses were identical in all three anatomic sites. Cystic fluid was identified by infrared spectrophotometry as an all-methyl silicone polymer. The presence of silicone fluid in the abdominal wall and inguinal region is explained by gravitational migration from its initial site of injection in the breasts—a finding not previously reported, to our knowledge.