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To the Editor.—
The good results obtained in the treatment of hyperkeratotic lesions with a 5% fluorouracil ointment1-3 suggested the possibility of treating patients who have porokeratosis of Mibelli with this drug. This rare disease is not grave but recurs frequently, when treated by surgery, electrocoagulation, or dry ice.4,5
Six patients from the outpatient Department of Dermatology of the Instituto Português de Oncologia de Francisco Gentil, Lisbon, were selected. As the lesion of porokeratosis of Mibelli is so typical and the clinical diagnosis so easy, histologic confirmation was not considered necessary; the resulting surgical trauma in such tiny lesions could, eventually, hinder the evaluation of the treatment.The patients were two men and four women, with ages ranging from 30 to 51 years. Two of the women were sisters. The lesions had been present for three months in one case, six months in one, four years
Gonçalves JCA. Fluorouracil Ointment Treatment of Porokeratosis of Mibelli. Arch Dermatol. 1973;108(1):131-132. doi:10.1001/archderm.1973.01620220085026