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To the Editor.—
I was very interested to read of the work done by Drs. Leyden and Kligman, which was published in the Archives (106:924, 1972).Since February 1972, I have treated nine patients who had scalp alopecia areata with triamcinolone acetonide in dimethyl sulfoxide; a solution of triamcinolone acetonide in purified undiluted dimethyl sulfoxide was used (5 mg/ml in five patients, 10 mg/ml in four patients). Untreated scalp patches served as control. The preparation was applied with a brush three to four times over a period of two to four weeks. The patients occasionally complained of a transient stinging at the site and time of application. Only two patients showed regrowth, which could reasonably be attributed to the therapy.However, I have so far been impressed with application of this local preparation (10 mg/ml) once daily, as compared to control solutions, in widespread granuloma annulare, psoriasis, and in
Verbov J. Steroid Solution Treatment of Alopecia Areata. Arch Dermatol. 1973;108(1):135. doi:10.1001/archderm.1973.01620220089035