Whether antibiotics should be combined with topical steroids in the treatment of chronic dermatoses is a question that is extraordinarily difficult to answer. The alternative proposed in this study is appraisal of efficacy in experimental human infection with Staphylococcus aureus and Candida albicans. With a broad spectrum steroid-antibiotic combination containing triamcinolone acetonide, neomycin gramicidin, and nystatin, it was possible to show that omission of any one component decreased the effectiveness of the mixture. The steroid by itself suppressed the experimental lesion without influencing the multiplication of the pathogen.
Marples RR, Rebora A, Kligman AM. Topical Steroid-Antibiotic CombinationsAssay of Use in Experimentally Induced Human Infections. Arch Dermatol. 1973;108(2):237-240. doi:10.1001/archderm.1973.01620230037013