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Original Contribution
August 1973

Antibodies Against the Cytoplasm of Human Epidermal Cells

Author Affiliations

From the Immunofluorescence Laboratory, Department of Dermatology, New York University School of Medicine, New York.

Arch Dermatol. 1973;108(2):241-244. doi:10.1001/archderm.1973.01620230041014

Antibodies against the cytoplasm of normal human epidermal cells were found in 4 of 23 (17%) normal persons, 12 of 57 (21%) patients with various dermatoses, 11 of 34 (32%) patients with malignant tumors, and 3 of 11 (27%) patients with malignant melanoma. These antibodies react against several different cytoplasmic antigens, some of which appear to be tissue- and species-specific, while others may also be present in heterologous stratified epithelial or smooth muscle cells.