Antibodies against the cytoplasm of normal human epidermal cells were found in 4 of 23 (17%) normal persons, 12 of 57 (21%) patients with various dermatoses, 11 of 34 (32%) patients with malignant tumors, and 3 of 11 (27%) patients with malignant melanoma. These antibodies react against several different cytoplasmic antigens, some of which appear to be tissue- and species-specific, while others may also be present in heterologous stratified epithelial or smooth muscle cells.
Bystryn J, Abel E, Weidman A. Antibodies Against the Cytoplasm of Human Epidermal Cells. Arch Dermatol. 1973;108(2):241-244. doi:10.1001/archderm.1973.01620230041014