Two sisters with dermolytic bullous dermatosis (epidermolysis bullosa dystrophica) were treated with vitamin E in a controlled double-blind crossover study. Both showed marked reduction in blister formation while on the study drug as compared to the control medication. The mechanism of action of vitamin E in the mechanobullous diseases is unknown.
Smith EB, Michener WM. Vitamin E Treatment of Dermolytic Bullous DermatosisA Controlled Study. Arch Dermatol. 1973;108(2):254-256. doi:10.1001/archderm.1973.01620230050017