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To the Editor.
I have received a letter of inquiry as to the composition of pyritinol.The chemical formula of pyritinol follows: bis[3-hydroxy-4-hydroxymethyl-2-methylpyridyl-(5)-methyl]-disulfide dihydrochloride monohydrate. The structure is shown in the Figure.The references in which this information appears are Wiener Medizinische Wochenschrift (114:105, 1964); Arzneimittel-Forschung (14:26, 1964); and Med Exp (7:144, 1962).
Ishibashi A. Composition of Pyritinol. Arch Dermatol. 1973;108(3):423. doi:10.1001/archderm.1973.01620240069022