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In the early part of this century, Landsteiner showed that chemicals of small molecular weight could function as antigens when coupled to protein carriers of large molecular weight. He correctly anticipated the subsequent course of research on the problems of drug allergy, which in his day were comparatively minor. In this text, a comprehensive review of the problem of hypersensitivity to drugs is taken. Numerous aspects of drug allergy, beginning with the affinity of the various drugs to proteins, the reactivity in terms of formation of covalent bonds with proteins, the immune response, and the various aspects of drug hypersensitivity in terms of organ involvement, are discussed in considerable detail. The book is divided into two sections that deal with the principles of drug hypersensitivity including most of the subjects just mentioned (chapters 1 through 7) with the reactions in specific organs and organ systems caused by drug hypersensitivity.
Gleich GJ. Hypersensitivity to Drugs. Arch Dermatol. 1973;108(3):442. doi:10.1001/archderm.1973.01620240082038