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October 1973

Focal Dermal HypoplasiaA Nine-Year Follow-Up Study

Author Affiliations


From the Department of Dermatology, Tufts School of Medicine and Boston City Hospital, Boston (Drs. Gottlieb and Fisher), and the Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston (Dr. Violin). Dr. Gottlieb is now at the University Medical Building, Washington, DC. Dr. Fisher is now with the Department of Dermatology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

Arch Dermatol. 1973;108(4):551-553. doi:10.1001/archderm.1973.01620250035010

The only patient known to have unilateral anophthalmia as part of the syndrome of focal dermal hypoplasia (Goltz syndrome) was reexamined dermatologically after a lapse of nearly nine years. In addition to the more severe anetoderma, depigmentation, and nail dystrophy, the patient had developed perioral wart-like lesions. Other new findings included malformed teeth with hypoplastic enamel, mental retardation, and possible urinary abnormality.

A review of the literature disclosed two more cases of apparent focal dermal hypoplasia; these were previously reported as other entities. Contrary to earlier thought, the condition may be found in males.