The only patient known to have unilateral anophthalmia as part of the syndrome of focal dermal hypoplasia (Goltz syndrome) was reexamined dermatologically after a lapse of nearly nine years. In addition to the more severe anetoderma, depigmentation, and nail dystrophy, the patient had developed perioral wart-like lesions. Other new findings included malformed teeth with hypoplastic enamel, mental retardation, and possible urinary abnormality.
A review of the literature disclosed two more cases of apparent focal dermal hypoplasia; these were previously reported as other entities. Contrary to earlier thought, the condition may be found in males.
Gottlieb SK, Fisher BK, Violin GA. Focal Dermal HypoplasiaA Nine-Year Follow-Up Study. Arch Dermatol. 1973;108(4):551-553. doi:10.1001/archderm.1973.01620250035010