To the Editor.—
In a recent article, Knight et al1 report the occurrence of a basal cell carcinoma and a malignant melanoma in a patient with neurofibromatosis. The authors emphasize the possibly increased incidence of other cutaneous neoplasms in neurofibromatosis. This view might be supported by the fact that the association of neurofibroma with nevoid basal cell carcinoma has been described in some patients, two of which I have observed.
Review of Cases
In 1938, Halter2 reported the case of a 38-year-old man with basal cell carcinomas of the face and trunk, and slight kyphoscoliosis. The patient had, in addition, a neurofibroma and two café au lait spots; one of the spots covered a large area of the body.
In 1940, Carol et al3 reported the cases of a mother and daughter who were suffering from neurofibromatosis and congenital heart-block. Multiple nodular alterations
Happle R. Neurofibroma and Nevoid Basal Cell Carcinoma. Arch Dermatol. 1973;108(4):582-583. doi:10.1001/archderm.1973.01620250062028