In patients with secondary syphilis, reversal to seronegativity is variable and no current schedule produces seroreversal in all patients with secondary syphilis within two years.
We treated 40 patients who had secondary syphilis with a total dose of 6,000,000 units of penicillin G benzathine given over a six-to ten-day period and produced seroreversal in all cases. The schedule consisted of 2,400,000 units followed by 2,400,000 units three to five days later and 1,200,000 units another three to five days later.
This is proposed as a new schedule for the treatment of secondary syphilis.
Durst RD, Sibulkin D, Trunnell TN, Allyn B. Dose-Related Seroreversal in Syphilis. Arch Dermatol. 1973;108(5):663-664. doi:10.1001/archderm.1973.01620260013003