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November 1973

Dose-Related Seroreversal in Syphilis

Author Affiliations

New York

From the Department of Dermatology, New York University School of Medicine, and the Service of Dermatology and Syphilology, Bellevue Hospital Center, New York.

Arch Dermatol. 1973;108(5):663-664. doi:10.1001/archderm.1973.01620260013003

In patients with secondary syphilis, reversal to seronegativity is variable and no current schedule produces seroreversal in all patients with secondary syphilis within two years.

We treated 40 patients who had secondary syphilis with a total dose of 6,000,000 units of penicillin G benzathine given over a six-to ten-day period and produced seroreversal in all cases. The schedule consisted of 2,400,000 units followed by 2,400,000 units three to five days later and 1,200,000 units another three to five days later.

This is proposed as a new schedule for the treatment of secondary syphilis.