The classic and currently accepted concept that large numbers of lesions of eccrine hidrocystomas occur almost exclusively in women exposed to hot, moist environments appears to be no longer valid. In this study of 45 patients with hidrocystomas, 40% were men, 80% had solitary lesions, and 93% had no more than four lesions. Ecologic and other explanations are offered for these changes in presentation. It is possible to distinguish hidrocystomas from basal cell carcinoma and other tumors by noting the small, translucent, smooth, shiny, often bluish colored, domeshaped cystic structure that occurs most often in a periorbital area. The histologic finding of an intradermal, unilocular cyst with a thin wall composed of two layers of eosinophilic-staining cuboidal cells confirms the diagnosis and distinguishes the structure from apocrine hidrocystoma (cystadenoma).
Smith JD, Chernosky ME. Hidrocystomas. Arch Dermatol. 1973;108(5):676-679. doi:10.1001/archderm.1973.01620260026008