A 70-year-old man underwent surgical removal of a thymoma in 1957. After a 13-year period, he developed pemphigus erythematosus that three years later became markedly exacerbated by an allergic contact dermatitis. Antibodies to squamous epithelial intercellular substance, to skeletal muscle, and to nuclei were demonstrated by immunofluorescence. To our knowledge, this is the first report documenting exacerbation of pemphigus by allergic contact dermatitis and the sixth report of the occurrence of thymoma and pemphigus in the same patient.
Lynfield YL, Pertschuk LP, Zimmerman A. Pemphigus Erythematosus Provoked by Allergic Contact DermatitisOccurrence Many Years After Thymoma Removal. Arch Dermatol. 1973;108(5):690-693. doi:10.1001/archderm.1973.01620260038014