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To the Editor.—
In answer to the observations and questions in the letter of Drs. Johnson and Fusaro, we would like to submit the following.
Cyclic AMP and theophylline should be left out of the "Material and Methods" section.
α-Glucosidase was originally a gift of Dr. Huijing and recently has been purchased from Boehringer Mannheim Corp. The preparation was not supplemented with amylase; we merely stated that it contained amylase.
Drs. Johnson and Fusaro doubt the possibility of producing skin slices that consistently contain approximately 85% epidermis when an invariant setting of 0.2 mm is used on the keratome, since psoriatic epidermis is so much thicker than normal epidermis. We wish it was so simple as merely changing the spacing of the blade; however, it is not. Using a single unchanged setting and the same unchanged blade to remove slices of skin from involved and uninvolved
Halprin KM. Glycogen Turnover in Epidermis-Reply. Arch Dermatol. 1973;108(5):725-726. doi:10.1001/archderm.1973.01620260069030