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January 1974

Localized Epidermolysis BullosaReport of Two Cases and Evaluation of Therapy With Glutaraldehyde

Author Affiliations


From the Division of Dermatology, Ottawa General Hospital and the University of Ottawa, Ottawa.

Arch Dermatol. 1974;109(1):70-72. doi:10.1001/archderm.1974.01630010046011

In two patients with localized epidermolysis bullosa (recurrent bullous eruption of the hands and feet or Weber-Cockayne syndrome), experimentally induced blisters were studied histopathologically. The blisters showed cleft formation in the suprabasal layer of the epidermis. Therapy with topically applied 10% glutaraldehyde was found to be beneficial, but the irritant and skin-sensitizing side-effects of this chemical proved to be a limiting factor in its use.