A widespread acanthosis nigricans preceded the onset of and resolved together with the remission of a cerebral encephalopathy. Due to the extensive nature of the eruption, an internal malignant tumor or endocrinopathy was initially suggested.
Scott RW, Klein AW, Leyden JJ. Acanthosis Nigricans Associated With a Benign Encephalopathy. Arch Dermatol. 1974;109(1):78-80. doi:10.1001/archderm.1974.01630010054013