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Article
January 1974

Comment on Vaccination During Pregnancy

Arch Dermatol. 1974;109(1):97. doi:10.1001/archderm.1974.01630010069023

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Abstract

To the Editor.—  In the April 1973 issue of the Archives, Carney et al, in their article on eczema vaccinatum and eczema herpeticum in Darier disease, state that one study reported a 50% rate of congenital malformations in offspring of women vaccinated during pregnancy. They quote as their reference for this statement an article by MacArthur, which appeared in Lancet (2:1104, 1952), titled "Congenital Vaccinia and Vaccinia Gravidarum."On checking this reference, I found that MacArthur's findings were incorrectly interpreted. He found that out of a total of 67 pregnant women vaccinated during the first trimester, 24% "failed to give birth to a normal child." The percentage of women vaccinated in the second and third months of pregnancy who did not give birth to normal children was 47%. However, on analyzing these cases, only one patient was documented as having produced a child with a congenital abnormality, the nature

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